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  • Title: Stimulation of granulocyte adhesiveness by the chemotactic peptide N-formyl-L-methionyl-L-phenylalanine.
    Author: Patrone F, Dallegri F, Sacchetti C.
    Journal: Res Exp Med (Berl); 1980; 177(1):19-22. PubMed ID: 7403684.
    Abstract:
    The in vitro effects of the peptide N-formyl-L-methionyl-L-phenylalanine on granulocytes adhesiveness and chemotaxis were investigated. N-formyl-L-methionyl-L-phenylalanine, when used at concentration chemotactically effective, increased significantly granulocyte adhesiveness. When granulocyte adhesiveness was inhibited by colchicine, the inhibition could not be reversed by subsequent treatment with N-formyl-L-methionyl-L-phenylalanine. These results suggest that microtubular system is involved in the stimulation of granulocyte adhesiveness by N-formyl-L-methionyl-L-phenylalanine.
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