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  • Title: The distribution of albumin and immunoglobulin G in the glomerular capillary wall in aminonucleoside nephrosis.
    Author: Ryan GB, Hein SJ, Karnovsky MJ.
    Journal: Pathology; 1978 Oct; 10(4):335-41. PubMed ID: 740408.
    Abstract:
    Using an ultrastructural immunoperoxidase technique, the distribution of endogenous albumin and immunoglobulin G was examined in superficial glomeruli of Munich-Wistar rats with aminonucleoside nephrosis. In glomerular capillaries in which the external surface of the glomerular basement membrane (GBM) was completely covered with spread expanses of epithelial cytoplasm, albumin and IgG were distributed normally, with no detectable penetration beyond the endothelial fenestrae. However, at sites of focal loss of the epithelial covering of the GBM, both albumin and IgG were found to penetrate the GBM. These results suggest that, in this experimental model, plasma proteins leak into the urine at sites of glomerular epithelial denudation.
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