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  • Title: Studies on quantitative relationships between the structure and in vitro tuberculostatic potency of 2-cyanomethylbenzimidazole derivatives.
    Author: Kaliszan R, Milczarska B, Lega B, Szefer P, Janowiec M.
    Journal: Pol J Pharmacol Pharm; 1978; 30(4):585-91. PubMed ID: 740561.
    Abstract:
    Quantitative relationships were studied between in vitro tuberculostatic potency and physico chemical parameters relating to the structure of 2-cyanomethylbenzimidazoles. The activity of the compounds was found to be mathematically described as a square function of molar refractivity of the substituent or the RM values and a linear function of the wavelength at the absorption maximum or the connectivity index for the aromatic ring in the substituent. The equation was obtained, statistically significant on the 99% level and describing of about 83% of variance in activity data, which may be of value for the design of new active derivatives.
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