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  • Title: Pulmonary alveolar proteinosis: the diagnosis by segmental lavage.
    Author: Martin RJ, Coalson JJ, Rogers RM, Horton FO, Manous LE.
    Journal: Am Rev Respir Dis; 1980 May; 121(5):819-25. PubMed ID: 7406316.
    Abstract:
    Histologic findings from segmental lavage material via the fiberoptic bronchoscope were evaluated as a means of diagnosing pulmonary alveolar proteinosis. Active cases of alveolar proteinosis yielded grossly opaque and/or milky effluents. The unique histologic findings in alveolar proteinosis included: (1) very few alveolar macrophages (2) large acellular eosinophilic bodies in a diffuse background of eosinophilic granules, and (3) periodic acid-Schiff staining of the proteinaceous material with a lack of significant alcian blue staining. Thus, the diagnosis of pulmonary alveolar proteinosis can be made by evaluation of the clinical setting and histologic findings of the effluent material from a segmental lavage.
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