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  • Title: Linkage of adult alpha- and beta-globin genes in X. laevis and gene duplication by tetraploidization.
    Author: Jeffreys AJ, Wilson V, Wood D, Simons JP, Kay RM, Williams JG.
    Journal: Cell; 1980 Sep; 21(2):555-64. PubMed ID: 7407927.
    Abstract:
    We have used cloned adult X. laevis alpha- and beta-globin cDNAs to analyze globin genes in X. laevis DNA. We detected alpha 1- and beta 1-globin genes which contain intervening sequences and code for the major adult globins, plus additional diverged alpha 2- and beta 2-globin genes of unknown coding potential. Unlike the case in mammals, the X. laevis alpha 1- and beta 1-globin genes are closely linked and occur in the sequence 5'-alpha 1-9 kb-beta 1-3'. The alpha 2- and beta 2-globin genes are also linked, and analysis of globin genes in X. tropicalis suggests that this duplication of an alpha-beta-globin gene pair in X. laevis is the result of chromosome duplication by tetraploidization. The close linkage of alpha- and beta-globin genes in Xenopus provides evidence that vertebrate alpha- and beta-globin genes evolved by tandem duplication of a single primordial globin gene.
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