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  • Title: Long-term effects of continuous exposure to amphetamine on brain dopamine concentration and synaptosomal uptake in mice.
    Author: Steranka LR, Sanders-Bush E.
    Journal: Eur J Pharmacol; 1980 Aug 08; 65(4):439-43. PubMed ID: 7408949.
    Abstract:
    Continuous release of p-chloroamphetamine from subcutaneously implanted minipumps for 3 days decreased brain 5-hydroxytryptamine, but not norepinephrine or dopamine, when analyzed 2 weeks later. In contrast, 2 weeks after infusion of amphetamine, whole brain dopamine but not 5-hydroxytryptamine or norepinephrine, was decreased. Also, the high affinity uptake of [3H] dopamine was markedly and selectively reduced in striatal synaptosomes. Thus, neurotoxicity is apparently not unique to halogenated amphetamine derivatives, but is produced by amphetamine itself if administered continuously.
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