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  • Title: The permeability of the human red cell to deuterium oxide (heavy water).
    Author: Karan DM, Macey RI.
    Journal: J Cell Physiol; 1980 Aug; 104(2):209-14. PubMed ID: 7410489.
    Abstract:
    Using a stopped-flow device, the osmotic water permeability of human red cells to D2O and H2O was studied as a function of temperature and under the influence of the sulfhydryl reagent paracholoromercuribenzene sulfonic acid (PCMBS), an inhibitor of water transport. The ratio, permeability (D2O)/permeability (H2O) at each temperature can be predicted simply by assuming that permeability varies inversely with macroscopic viscosity. When water permebility is inhibited with PCMBS, this dependency on viscosity vanishes; the inhibited permeabilities in D2O and H2O are indistinguishable.
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