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Title: Evaluation of 2-azabicyclo[2.2..2]octane analogs of 4-anilidopiperidine analgesics. Author: Borne RF, Law SJ, Kapeghian JC, Masten LW. Journal: J Pharm Sci; 1980 Sep; 69(9):1104-6. PubMed ID: 7411420. Abstract: Eight analogs of the fentanyl-type analgesics, in which the piperidine ring is restricted into a boat conformation, were evaluated for analgesic activity. All analogs were less active than fentanyl, but interesting conformational and structural relationships were observed. Results of the study are discussed.[Abstract] [Full Text] [Related] [New Search]