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  • Title: Tumor inhibitory triazenes. 2. Variation of antitumor activity within an homologous series.
    Author: Wilman DE, Goddard PM.
    Journal: J Med Chem; 1980 Sep; 23(9):1052-4. PubMed ID: 7411549.
    Abstract:
    An homologous series of water-soluble, chemically stable analogues of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC) has been prepared with activity comparable to DTIC in an experimental tumor system. The antitumor activity of this series of 3-alkyl-1-(4-carboxyphenyl)-3-methyltriazenes rapidly diminishes at alkyl chain lengths greater than pentyl. Partition coefficients were determined, but no relationship between these and antitumor activity could be established.
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