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  • Title: Blockade of the rate and force responses to phenylephrine on rat atria with labetalol.
    Author: Simpson WW, McNeill JH.
    Journal: Res Commun Chem Pathol Pharmacol; 1980 Aug; 29(2):373-6. PubMed ID: 7414055.
    Abstract:
    Evidence suggests that the combined alpha and beta adrenergic agonist phenylephrine influences cardiac tissue through stimulation of both alpha and beta adrenoceptors. Phenylephrine effected a positive inotropic and chronotropic response in paced (1 Hz) left and spontaneously beating right atria, respectively. In the presence of the combined alpha and beta adrenoceptor antagonist labetalol (5 x 10(-6)M) the rate and force responses to phenylephrine were completely abolished. The data suggest that phenylephrine exerts its inotropic and chronotropic effects through both alpha and beta adrenoceptors in such a way that both adrenoceptors must be blocked in order to completely abolish the responses induced by the dual agonist.
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