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  • Title: [State of the hypothalamo-hypophyseo-thyroid system in severe craniocerebral injuries].
    Author: Shutov AA, Chudinov AA, Pleshkova NM.
    Journal: Zh Vopr Neirokhir Im N N Burdenko; 1980; (3):23-7. PubMed ID: 7415734.
    Abstract:
    The amount of the pituitary thyrotropic hormone and the thyroid hormones (T4, T3, KET) in the serum of 30 patients with severe craniocerebral trauma was studied in dynamics from the 1st and until the 30th day of the disease. Marked disorders in the hypothalamo-hypophyseal-thyroid system were revealed in the form of hypersecretion of the thyrotropic hormone and profound inhibition of the thyroid function. Both the transport-organic and the metabolic phase of metabolism of the thyroid hormones suffer, with prevalent changes in the former. Disturbed thyroid metabolism is an essential link in the pathogenesis of a severe craniocerebral trauma and calls for the corresponding correction.
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