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  • Title: Tumor pathophysiology: the perfusion model.
    Author: Gullino PM.
    Journal: Antibiot Chemother (1971); 1980; 28():35-42. PubMed ID: 7416730.
    Abstract:
    A procedure for perfusing a tumor as an isolated organ separated from the host is described. Details of the following steps have been outlined: preparation of a tumor connected to the host by a single artery and vein, transfer of the tumor from the host to the ex vivo perfusion system, constitution of the perfusion circuit, composition of the perfusates, control of vascular and metabolic parameters during perfusion.
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