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  • Title: [Cyto-histochemical study of morphogenesis of experimental nonspecific pneumonia].
    Author: Iashchenko LV.
    Journal: Arkh Patol; 1980; 42(5):19-26. PubMed ID: 7416996.
    Abstract:
    Examination of macrophages, polymorphonuclear leukocytes (PMNL) and lymphocytes of the trachea, PMNL and blood lymphocytes, of the condition of pulmonary tissue in the time course of the process (1st day--l months) revealed an association between the developing cellular and tissue changes. The development of alterations in the lungs with predominant anabolic changes and moderate exudation are characterized by a decrease in the content of nucleoproteins (deoxyribonucleoproteins, ribonucleoproteins), and activity of NAD-diaphorase and alkaline phosphatase, an increase in the activity of acid phosphatase in the above-mentioned cells of the trachea and blood as well as by increased permeability of lysosomal membranes and degeneration of macrophages, PMNL and lymphocytes of the trachea. The above cellular changes in combination with increased permeability of PMNL and blood lymphocyte lysosomal membranes correspond to the development in the lungs of catabolic alterative lesions, marked exudation, and suppurative-necrotic processes. The increase in the content of nucleoproteins and NAD-diaphorase and alkaline phosphatase activity and the decrease in the acid phosphatase activity are accompanied by activation of proliferation in the lungs.
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