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  • Title: [Focal edema of the intima as a preatherosclerotic arterial lesion].
    Author: Vikhert AM, Rozinova VN.
    Journal: Arkh Patol; 1980; 42(6):26-33. PubMed ID: 7417011.
    Abstract:
    A number of histological, histochemical and immunomorphological methods were used to study focal edema of the aortal intima in children and young subjects and its association with the development of atherosclerotic alterations. The main manifestations of the focal edema of the intima include focal accumulation of insudate consisting of serous or serous-fibrinous liquid, accumulation of metachromatic substances, damage of collagen and elastic fibers, proliferation of smooth muscle cells and their fatty metamorphosis. Later, signs of organization and sclerosis of the edematous zone develop. The following stages of the development of focal intimal edema may be distinguished: simple or serous edema; serous-fibrinous edema; proliferation of smooth muscle cells followed by their fatty degeneration and extracellular release of lipids; organization or sclerosis of the edema focus. It is assumed that late stages of the development of focal edema of the intima are associated with fibrous and fibrous-lipid atherosclerotic plaques.
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