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  • Title: Chemotaxis in yersinia arthritis. HLA-B27 positive neutrophils show high stimulated motility in vitro.
    Author: Leirisalo M, Repo H, Tiilikainen A, Kosunen TU, Laitinen O.
    Journal: Arthritis Rheum; 1980 Sep; 23(9):1036-44. PubMed ID: 7417352.
    Abstract:
    Chemotaxis, chemokinesis, and spontaneous locomotion of polymorphonuclear leukocytes (PMNs) of yersinia arthritis (YA) patients and healthy subjects with or without HLA-B27 were studied by agarose assay and membrane filter technique. HLA-B27 positive healthy control subjects and yersinia patients showed significantly higher response to chemotactic stimulus than HLA-B27 negative controls. Consequently, the high response was associated with HLA-B27 irrespective of YA. The high responder PMNs may contribute to the more severe inflammatory symptoms in YA patients with HLA-B27.
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