These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Fatty acid synthesis in brown adipose tissue in relation to whole body synthesis in the cold-acclimated golden hamster (Mesocricetus auratus).
    Author: Trayhurn P.
    Journal: Biochim Biophys Acta; 1980 Oct 06; 620(1):10-7. PubMed ID: 7417474.
    Abstract:
    The synthesis of fatty acids has been measured in vivo with 3H2O in brown adipose tissue, the liver, white adipose tissue and the 'carcass' of cold-acclimated (4 degrees C) golden hamsters (Mesocricetus auratus), and the results compared with those of warm-acclimated (30 degrees C) animals. In warm-acclimated hamsters the highest rate of synthesis was found in the liver, which accounted for more than a quarter of the total body synthesis. Cold-acclimation led to an almost 3-fold increase in whole-body fatty acid synthesis, compared to warm-acclimated animals, and this resulted from increases in all the individual tissues examined, particularly in brown adipose tissue. In cold-acclimated hamsters the rate of synthesis appeared to be similar in brown adipose tissue and the liver. However, studies with Triton WR 1339 suggested that at least one-half of the apparent synthesis in brown adipose tissue resulted from the rapid incorporation into the tissue of fatty acids synthesised elsewhere. On a whole-body basis, the liver made a much greater contribution than brown adipose tissue to total fatty acid synthesis in cold-acclimated hamsters; this is in marked contrast to the relative importance of these two tissues in cold-acclimated rats and mice. It is concluded that in the hamster, an animal widely used for studying the mechanisms of non-shivering thermogenesis in brown adipose tissue, the fatty acids utilised for generating thermoregulatory heat are synthesised principally in tissues other than brown adipose tissue.
    [Abstract] [Full Text] [Related] [New Search]