These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of a 15(S)-15-methyl prostaglandin F2 alpha (methyl ester) suppository upon termination of early pregnancy.
    Author: Roux JF, Southern E, Gutknecht G.
    Journal: Contraception; 1980 Jul; 22(1):57-61. PubMed ID: 7418407.
    Abstract:
    The administration of prostaglandin vaginally to 15 pregnant patients in the first trimester caused abortion in 73% of the cases. Although other regimens have been reported to be effective and well tolerated, the single 3 mg. suppository of 15(S)-15-methyl prostaglandin F2 alpha (methyl ester) utilized in the present study was associated with a significant incidence of side effects and a relatively high failure rate. However, if an analogue or improved treatment regimen could be found which is more efficient, as well as more pleasant in its affects, the availability and the cost of early abortion would be improved with a concomitant effect on the incidence of late abortion and its complications. The efficacy of 15(S)-15-methyl-prostaglandin F2 alpha (methyl ester) as a first trimester abortifacient was studied when delivered via vaginal suppository in 15 women. Each patient received 1 vaginal suppository containing 3 mg of the methyl ester and each was closely observed for the following 10 hours. Rate of complete abortion as demonstrated by examination and negative pregnancy tests 2 weeks postadministration of the suppository was 73%; 27% of the cases were judged to have had incomplete abortions. These incomplete aborters were completed by suction or regular curettage. 13% of patients showed a moderate decrease in systolic and diastolic pressure. 93% of women started to bleed within 10 hours; blood loss estimate averaged 41.5 ml. Diarrhea was the main side effect, occurring in 73% of cases, whereas 47% suffered up to 3 episodes of vomiting. Though failure rate and side effects were too high, it is thought that another analog may overcome these problems.
    [Abstract] [Full Text] [Related] [New Search]