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  • Title: [Spontaneous regression of the changes in lipid and lipoprotein metabolism in normotensive and spontaneously hypertensive rats when switched from an atherogenic to a normal diet].
    Author: Orbetsova VTs.
    Journal: Eksp Med Morfol; 1980; 19(3):172-9. PubMed ID: 7418647.
    Abstract:
    The author examined the spontaneous regression of the changes in the levles of serum and liver lipids and lipoproteins in normotonic Wistar rats and Okamoto--Aoki rats with spontaneous hypertension after turning from long-term atherogenic to normal diet. The data on the dynamic examination of the changes in Wistar rats showed that at early, stages the levels of serun lipids were lowered but more slowly than those of the liver lipids. Furthermore the levels of serum triglycerides were even elevated significantly which suggested an increased entry from the extrahepatic tissues i.g. intensification of lipid turnover and centripetal transport in lipids. After 50 days of normal feeding the levels of serum and liver lipids were normalized in Wistar rats. The changes in lipoproteins were most permanent, which suggested their active participation in realization of the influence of the alimentary factor. In spontaneously hypertensive rats there was much weaker dynamics in serum lipids under the influence of the atherogenic diet for which was of significance the smaller course of the diet as well. Refeeding with normal diet normalized liver lipids, but not the levels of total lipids and lipoproteins solely elevated under the influence of the atherogenic diet. She discusses eventual mechanisms of the observed phenomena.
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