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  • Title: Inhibition of isolated rat liver RNApolymerases I and II by aminoacridines.
    Author: Zoncheddu A, Accomando R, Calendi E, Orunesu M.
    Journal: Experientia; 1980 Oct 15; 36(10):1151-2. PubMed ID: 7418788.
    Abstract:
    9-Aminoacridine and 2 derivatives which contain hydroxyalkylic or aminoalkylic side chains in the 9-position totally inhibit the transcription of calf thymus DNA by rat liver RNA polymerases I and II. This inhibitory action does not always appear to be completely related to the ability of aminoacridines to intercalate into the DNA template.
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