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  • Title: Prediction of late ischemic complications after cerebral aneurysm surgery by the intraoperative measurement of cerebral blood flow.
    Author: Pickard JD, Matheson M, Patterson J, Wyper D.
    Journal: J Neurosurg; 1980 Sep; 53(3):305-8. PubMed ID: 7420145.
    Abstract:
    The response of cerebral blood flow (CBF) to drug-induced hypotension was measured in 20 patients who underwent craniotomy for clipping of a cerebral aneurysm following subarachnoid hemorrhage. A modified intravenous xenon-133 injection technique was used to monitor CBF. In 15 patients, CBF increased significantly with hypotension, and only one developed a late neurological deficit. In five patients, CBF fell with halothane-induced hypotension, and four developed delayed neurological deficits. Measurement of the intraoperative CBF response to halothane-induced hypotension may reveal those patients at greatest risk of developing late neurological deficits and who require more intensive postoperative monitoring and early use of the induced hypertension technique.
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