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  • Title: Megadose corticosteroid therapy in systemic lupus erythematosus.
    Author: Fessel WJ.
    Journal: J Rheumatol; 1980; 7(4):486-500. PubMed ID: 7420330.
    Abstract:
    The therapeutic efficacy and upper limits of corticosteroid dosage in the treatment of collagen diseases have not been determined. Thirteen patients are reported (11 with systemic lupus erythematosus, 2 with polymyositis), 7 of whom had good clinical results from megadose dexamethasone therapy in the range of 1,300 to 7,200 mg during an acute stage of their disease. Of the 7, 5 patients also had improved laboratory findings; 3 also had improved radiolgic abnormalities. Complications seem no worse than from conventional high-dosage corticosteroid therapy.
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