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  • Title: Some properties of aminopropanol dehydrogenase in rat serum studied in normal conditions and in acute carbon tetrachloride poisoning.
    Author: Wyrebowska J, Jerzykowski T.
    Journal: J Toxicol Environ Health; 1980 May; 6(3):613-20. PubMed ID: 7420468.
    Abstract:
    Studies of aminopropanol dehydrogenase have shown no enzyme activity or very little activity in rat serum and in blood serum of healthy humans. After a single ip dose of CCl4 two enzymatic forms of aminopropanol dehydrogenase, reacting at different pH optima (alkaline and acid), appeared in the blood serum of rats. MFaximum enzyme activity at the alkaline pH appeared about 24 h after CCl4 administration in serum from young rats and after about 12 h in serum from mature rats. Activity values were about 90-150 mumol NAD reduced in 1 min per 1 l serum. Some biochemicl properties of the enzyme reacting at the alkaline pH optimum were studied. Aminopropanol dehydrogenase activity in serum of rats with acute CCl4 poisoning was determined by following the increase in absorbance at 340 nm due to the production of NADH. This enzyme, appearing in the serum after CCl4 poisoning, may be of interest as a potential indicator enzyme for clinical diagnosis.
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