These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Ionic mechanisms of the rapid (nicotinic) phase of the acetylcholine response of identified Planorbis neurons].
    Author: Ger BA, Zeĭmal' EV, Kachman AN.
    Journal: Neirofiziologiia; 1980; 12(5):533-40. PubMed ID: 7422039.
    Abstract:
    The response to electrophoretic application of acetylcholine and suberyldicholine was studied in two identified neurons (LPed-2 and LPed-3) isolated from Planorbarius corneus left pedal ganglion. Acetylcholine reversal potential was found to be significantly more negative with K(2)SO(4)-filled microelectrodes than with KCl-filled ones. Reversal potentials for both acetylcholine and suberyldicholine were shifted in the depolarizing direction when Cl- in external medium was partly replaced by SO(2-)(4). These results suggest the Cl--dependence of both acetylcholine and suberyldicholine responses in LPed-2 and LPed-3. Both reversal potentials are identical (-50 mV) in LPed-3, whereas in LPed-2 the acetylcholine reversal potential was significantly less negative (-46 mV comparing to -62 mV). Partial substitution of sodium ions by tris shifted the acetylcholine reversal potential (but not the reversal potential of suberyldicholine) towards the hyperpolarization in LPed-2. Benzohexonium produced the same effect. The conclusion is made that in LPed-2 acetylcholine activates cholinoreceptors controlling Na;ermeability, besides cholinoreceptors responsible for Cl- permeability, whereas suberyldicholine activates selectively only cholinoreceptors controlling Cl- permeability.
    [Abstract] [Full Text] [Related] [New Search]