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  • Title: Plasma levels of isosorbide dinitrate and the isosorbide mononitrates after increasing doses of a retard preparation of isosorbide dinitrate.
    Author: Bogaert MG, Rosseel MT.
    Journal: Nouv Presse Med; 1980 Sep 25; 9(34 Suppl):2424-7. PubMed ID: 7422532.
    Abstract:
    Different doses of a retard preparation of isosorbide dinitrate (40, 80 and 120 mg) were given in a cross-over design with one week intervals to 6 patients with angina pectoris. Plasma concentrations of isosorbide dinitrate and of the isosorbide 2- and 5-mononitrates were measured by a gas-liquid chromatographic method. The concentrations of isosorbide dinitrate rose with the dose given, and with the highest dose, levels above 5 ng/ml were obtained for 12 hours. Concentrations of the mononitrates were much higher than those of the parent compound.
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