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  • Title: Effects of oral pentaerythritol tetranitrate in cardiac failure and angina pectoris. Assessment by hemodynamic measurement and exercise capacity.
    Author: Amsterdam EA, Lee G, Awan NA, Low R, Mason DT.
    Journal: Nouv Presse Med; 1980 Sep 25; 9(34 Suppl):2443-6. PubMed ID: 7422533.
    Abstract:
    Oral pentaerythritol tetranitrate produces sustained beneficial hemodynamic effects in patients with cardiac failure of varied etiology. The principle action is a reduction of elevated left ventricular filling pressure. In a small group of angina patients, the oral nitrate in high dosage resulted in considerable increase in angina-limited exercise capacity compared to placebo for four hours following drug administration. No side effects were associated with ingestion of pentaerythritol tetranitrate in these investigations.
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