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  • Title: Post-amphetamine depression of self-stimulation responding from the substantia nigra: reversal by tricyclic antidepressants.
    Author: Kokkinidis L, Zacharko RM, Predy PA.
    Journal: Pharmacol Biochem Behav; 1980 Sep; 13(3):379-83. PubMed ID: 7422693.
    Abstract:
    The effects of long-term amphetamine treatment were examined on self-stimulation responding from the substantia nigra. Rates of self-stimulation responding were substantially depressed among rats chronically treated with amphetamine and tested in the absence of the drug. When rats were subsequently retested after a two day hiatus in which they received imipramine or amitriptyline, the post-amphetamine depression of rates of self-stimulation responding was mitigated. The efficacy of imipramine and amitriptyline in reversing the post-amphetamine depression of self-stimulation responding was also evident during a continuation of the drug (imipramine or amitriptyline)/test sequence, for seven test sessions. The results of the present investigation were related to changes in dopamine and acetylcholine neurotransmission following long-term amphetamine treatement.
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