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  • Title: Polymorphic acetylation of sulphamethazine in man: acetylator phenotype in sicklers and non-sicklers.
    Author: Jeyakumar LH, French MR.
    Journal: Toxicol Lett; 1980 Sep; 6(4-5):263-5. PubMed ID: 7423555.
    Abstract:
    The acetylator phenotype was determined for 183 Nigerians after administration of sulphamethazine at a dose level of 40 mg/kg body weight and analysis of urine after 6 h. Haemoglobin electrophoresis showed that 63 people (34.4%) carried the sickle cell trait. The % of slow acetylators amongst sicklers was 39.7 and amongst non-sicklers 40.8, a difference that was not significant.
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