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  • Title: [Investigations of combined injuries, 28th communication: Troubles of hemostatic equilibrium arising from radiation and combined injuries (author's transl)].
    Author: Boegelein K, Reichenbach-Klinke KE, Messerschmidt O.
    Journal: Strahlentherapie; 1980 Jun; 156(6):430-6. PubMed ID: 7423569.
    Abstract:
    In female mice the influence of total-body irradiation combined with excision of skin on the blood-clotting system was examined. Whereas the general tests of plasmatic coagulation showed no significant change, a biphasic course of coagulation disturbances in thrombelastography and euglobulin-clot-lysis following combined radiation injury was found. During the first time a pronounced increase of coagulability appeared, followed by the development of a hypocoagulability due to thrombocytopenia and functional disturbances of blood platelets. In this hemorrhagic period the euglobulin-clotlysis time was accelerated, but only after combined injury. Possible reasons are discussed.
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