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  • Title: The role of liver cytosolic aldehyde dehydrogenase in ethanol metabolism in DBA and C57Bl mice.
    Author: Smolen A, Atkinson N, Petersen DR.
    Journal: Adv Exp Med Biol; 1980; 132():627-34. PubMed ID: 7424733.
    Abstract:
    Cytosolic aldehyde dehydrogenase (AlDH) activity was increased in DBA and C57Bl mice following phenobarbital (Pb) treatment. The kinetic constants for the control and induced enzymes were similar in both inbred strains. The DBA mice showed enhanced rates of ethanol and acetaldehyde metabolism after Pb treatment, whereas the C57Bl mice did not. It was concluded that the cytosolic enzyme is more important for acetaldehyde metabolism in the DBA than in the C57Bl mice.
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