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  • Title: Epinephrine induces Ca2+ uptake in human blood platelets.
    Author: Owen NE, Feinberg H, Le Breton GC.
    Journal: Am J Physiol; 1980 Oct; 239(4):H483-H488. PubMed ID: 7425140.
    Abstract:
    Human blood platelets isolated by albumin density gradient centrifugation take up Ca2+ during 10(-6)M epinephrine-induced primary aggregation but not during 10(-6)M ADP-induced primary aggregation. Platelet uptake of Ca2+ is dose-dependent over a range of 10(-7) to 10(-5) M epinephrine. Antagonism of the platelet alpha-receptor by phentolamine (10(-6)M) results in inhibition of both epinephrine-stimulated Ca2+ uptake and aggregation. The Ca2+ antagonist verapamil (50 micro M) blocks Ca2+ uptake and epinephrine-induced aggregation, but not ADP-induced aggregation. The verapamil inhibition of aggregation is reduced on Ca2+ addition. These results suggest that epinephrine acts to stimulate primary platelet aggregation through a specific receptor interaction that results in a selective increase in platelet membrane permeability to Ca2+.
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