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  • Title: The use of prostaglandin E1 analogue pessaries in patients having first trimester induced abortions.
    Author: Nakano R, Hata H, Sasaki K, Yamoto M.
    Journal: Br J Obstet Gynaecol; 1980 Apr; 87(4):287-91. PubMed ID: 7426498.
    Abstract:
    A new prostaglandin analogue, 16,16-dimethyl=trans-delta 2-PGE1 methyl ester (16 me E1) was used for preoperative cervical dilatation in 23 pregnant women who had abortion induced for socio-economical reasons in the first trimester of pregnancy. A single vaginal pessary containing 1 mg 16 me E1 was inserted into the posterior fornix at 3-hour intervals. Thirteen (56.5 per cent) of the 23 patients had complete abortions and two patients (8.7 percent) had incomplete abortions. In six patients (26.1 per cent) the cervix was dilated to at least 10 mm and the remaining two patients (8.7 per cent) required mechanical dilatation at the time of vacuum evacuation. Apart from mild gastrointestinal symptoms, no serious side effects were noted. It is concluded that the new prostaglandin analogue, 16 me E1, could be used safely and effectively for preoperative dilatation of the cervix before surgical abortion in early pregnancy. 16,16-dimethyl-trans-delta2-prostaglandin E1 methyl ester (16 me E1), a new prostaglandin analog, was used for preoperative cercial dilatation in 23 pregnant woemn who had abortion induced in the first trimester for various socioeconomic reasons. The 16 me E1 was incorporated into a vaginal pessary containing 1 mg and this was inserted into the posterior fornix at 3-hour intervals, for a total of 5 pessary insertions. In 21 of 23 patients, either abortion occurred during the treatment period or the cervix dilated to at least 10 mm at the time of vacuum aspiration. 13 patients had complete abortions, 2 had incomplete abortions, and 6 had cervices dilated to greater than 10 mm. The remaining 2 patients required mechanical dilatation at the time of vacuum evacuation of uterine contents. There were some mild gastrointestinal side effects, judged inconsequential, and it is concluded that this new analog of PGE1 is indicated for use in preoperative cervical dilatation before surgical abortion in early pregnancy.
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