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  • Title: [Effect of diazepam and fenazepam on neural regulation of cerebral circulation].
    Author: Mirzoian RS, Gan'shina TS, Kosarev IV, Bendikov EA.
    Journal: Biull Eksp Biol Med; 1980 Sep; 90(9):305-8. PubMed ID: 7426731.
    Abstract:
    Diazepam and phenazepam produce a depressant action on reflex changes in the cerebral blood flow and increase the tone of cerebral vessels, induced by stimulation of the afferent fibers of A and C groups of somatic nerves. The drugs potentiate the processes of central inhibition of tonic sympathetic activity and of reflex somatosympathetic responses along with the decreased amplitude and potential frequencies on the EEC. Phenazepam exerts a more pronounced depressant effect on the nervous regulation of cerebral circulation. GABA-ergic mechanisms are suggested to participate in the action of diazepam and phenazepam on the central regulation of cerebral circulation.
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