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  • Title: [Effect of nonachlazine on the cardiac component of baroreceptor reflexes in unanesthetized cats].
    Author: Medvedev OS, Stepochkina NA, Matsievskiĭ DD.
    Journal: Biull Eksp Biol Med; 1980 Sep; 90(9):309-11. PubMed ID: 7426732.
    Abstract:
    Nonachlazin in doses of 1 and 6 mg/kg provoked a rise in the arterial pressure of cats by 7--20 mm Hg. Administration of 1 mg nonaclazin into the IV ventricle induced a similar elevation of arterial pressure. Premedication with propranolol (1--3 mg/kg) did not prevent the pressor reaction. In half of the experiments, nonachlazin (6 mg/kg) produced an appearance of Meyer's waves and inhibition of the cardiac component of the barorecptor reflex that is not related to the potentiation of the sympathetic effects on the heart.
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