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  • Title: Splenic size and function in adult coeliac disease.
    Author: Robinson PJ, Bullen AW, Hall R, Brown RC, Baxter P, Losowsky MS.
    Journal: Br J Radiol; 1980 Jun; 53(630):532-7. PubMed ID: 7426864.
    Abstract:
    Splenic scintigraphy was performed after measurement of 99Tcm-labelled heat-damaged red cell clearance in 29 patients with treated coeliac disease. Good correlation was found between splenic size and function using these techniques. 99Tcm-labelled sulphur colloid scintiscans were also performed in 24 coeliacs. Splenic volumes computed from colloid scans correlated well with those computed from red cell scans. Almost 50% of adult patients with treated coeliac disease have impaired splenic function, the incidence rising with increasing age of starting treatment. Sulphur colloid scintigraphgy provides a simple quantitative method of assessing splenic function in treated coeliac disease which can be used in exploring the possibilities of avoidance of the adverse effects of hyposplenism.
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