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  • Title: Inhibition of calcium oxalate crystal growth in urine during treatment with allopurinol.
    Author: Tiselius HG.
    Journal: Br J Urol; 1980 Jun; 52(3):189-92. PubMed ID: 7426978.
    Abstract:
    Twelve male patients with urolithiasis were treated with 300 mg allopurinol daily. Urinary urate decreased from 251 +/- 55 to 156 +/- 19 (mean +/- SD) mmol per mol creatinine. The inhibition of calcium oxalate crystal growth was measured in an in vitro system and the inhibition index increased from 0.51 +/- 0.06 to 0.57 +/- 0.08 (mean +/- SD). Urinary citrate excretion was unaffected by the treatment.
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