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  • Title: Successful treatment of metastatic sarcomas with cyclophosphamide, adriamycin, and DTIC (CAD).
    Author: Blum RH, Corson JM, Wilson RE, Greenberger JS, Canellos GP, Frei E.
    Journal: Cancer; 1980 Oct 15; 46(8):1722-6. PubMed ID: 7427876.
    Abstract:
    Fifty consecutive adults with sarcoma were treated with Adriamycin (45 mg/m2) on day 1, cyclophosphamide (500 mg/m2) on day 2, and DTIC (400 mg/m2) on days 1 and 2 (CAD). Of the 23 patients with measurable metastatic disease, 4 patients (17%) had a complete response, 9 patients (39%) had a partial response, 5 patients (22%) had stabilization, but 5 patients (22%) did not respond. The actuarial survival of complete and partial responders was 31.5 months compared to 5.5 months for non-responders (P < .005). Chemotherapy doses were escalated to a median lowest white count of 700 cells/mm3. Acute gastrointestinal toxicity and alopecia occurred in all patients. CAD differed from previously reported combinations by omission of vincristine, a two-day dose schedule and dose rate intensification. CAD is recommended for patients with metastatic sarcoma.
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