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  • Title: Comparison of sisomicin and gentamicin in the treatment of serious systemic infections.
    Author: Leal del Rosal P, Leal del Rosal L, Riosvelasco Carrasco AG, Aguirre Rascon E.
    Journal: Curr Med Res Opin; 1980; 6(10):663-9. PubMed ID: 7428404.
    Abstract:
    Sixty-nine hospitalized patients with serious systemic infections, mainly surgical wound infections, soft-tissue abscesses, peritonitis, or pneumonia, were treated either with sisomicin or gentamicin by parenteral administration for periods ranging from 5 to 14 days. In general, sisomicin-treated patients received a mean daily dosage of 2.6 to 3.9 mg/kg and gentamicin-treated patients 3.0 to 5.1 mg/kg. The results, based on the combined clinical and bacteriological responses, showed an overall cure rate of 74% for the 34 patients on sisomicin compared with 37% of the 30 patients on gentamicin for whom a definite evaluation could be made. This difference was statistically significant (p = 0.005). The bacteriological findings also suggest that sisomicin was more effective than gentamicin in eliminating Pseudomonas aeruginosa from infected patients. Local tolerance was good to both drugs. A change in auditory function was reported in 1 patient on gentamicin. Mild changes in renal function, possibly drug related, were recorded in 5 patients (1 on sisomicin and 4 on gentamicin).
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