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  • Title: Histoplasma capsulatum endocarditis cured by amphotericin B combined with surgery.
    Author: Bradsher RW, Wickre CG, Savage AM, Harston WE, Alford RH.
    Journal: Chest; 1980 Nov; 78(5):791-5. PubMed ID: 7428470.
    Abstract:
    A patient is reported who had Histoplasma capsulatum endocarditis, a rare form of disseminated histoplasmosis. He also had disseminated intravascular coagulopathy and defects in cell-mediated immune responses to Histoplasma antigens. Prompt etiologic diagnosis was made by stain of tissue from a mouth ulcer and confirmed by culture of the organism from blood. An echocardiogram compared to a previous normal echocardiogram indicated changes consistent with a vegetation. Histologic examination of the resected valve demonstrated organisms. Amphotericin B administration (3.4 g) plus an aortic valve replacement resulted in cure.
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