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  • Title: Effect of acyclovir on acute and latent herpes simplex virus infections in the rabbit.
    Author: Trousdale MD, Dunkel EC, Nesburn AB.
    Journal: Invest Ophthalmol Vis Sci; 1980 Nov; 19(11):1336-41. PubMed ID: 7429768.
    Abstract:
    Acyclovir, a new potent antiviral drug, was used to treat herpes simplex virus (HSV) infection in the rabbit ocular model. Acyclovir (3% ointment) used topically one to five times a day on acute ocular HSV infection gave beneficial results as measured by a reduction in corneal involvement, conjunctivitis, iritis, and corneal clouding. Topical treatment did not prevent the establishment of latent HSV infection. Intravenous acyclovir used two times a day (50 mg/kg) on rabbits with latent HSV infection appeared to suppress HSV in the nervous system but did not eradicate established latent HSV infection.
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