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  • Title: Microbial conversion of steffimycin and steffimycin B to 10-dihydrosteffimycin and 10-dihydrosteffimycin B.
    Author: Wiley PF, Elrod DW, Slavicek JM, Marshall VP.
    Journal: J Antibiot (Tokyo); 1980 Aug; 33(8):819-23. PubMed ID: 7429984.
    Abstract:
    It has been shown that steffimycin (1) and steffmycin B (2) are reduced at the C-10 carbonyl by Actinoplanes utahensis, UC-5885 and Chaetomium sp., UC-4634, respectively. Using cell-free extracts of the latter organism, the optimum conversion time, pH, and enzyme concentration have been determined for the conversion of 2 to 4. The biochemical conversion of 2 has been found to be TPNH linked.
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