These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Isolation of an intermediate of 2-deoxystreptamine biosynthesis from a mutant of Bacillus circulans.
    Author: Fujiwara T, Takahashi Y, Matsumoto K, Kondo E.
    Journal: J Antibiot (Tokyo); 1980 Aug; 33(8):824-9. PubMed ID: 7429985.
    Abstract:
    Eight 2-deoxystreptamine-negative (DOS-) mutants were isolated from various strains of Bacillus circulans, normally producing butirosin, xylostasin and ribostamycin. These mutants were classified into two groups (converter and secretor) by the simple method of cosynthesis using agar plate culture. One of the cosynthetic pairs, strain S-11, an intermediate of DOS biosynthesis, S-11-P, was isolated. This compound was converted to butirosin (BTN) effectively by strain 236. The structure of S-11-P was considered to be (1 L or 1 D)-1,3,5/2,4-5-amino-cyclohexanetetrol, and the pathway of DOS biosynthesis is discussed here.
    [Abstract] [Full Text] [Related] [New Search]