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  • Title: Production of a new aminoglycoside antibiotic by a mutant of Bacillus circulans.
    Author: Fujiwara T, Takahashi Y, Matsumoto K, Kondo E.
    Journal: J Antibiot (Tokyo); 1980 Aug; 33(8):836-41. PubMed ID: 7429987.
    Abstract:
    A new aminoglycoside antibiotic, S-11-A, was isolated from the fermentation broth of the 2-deoxystreptamine negative (DOS-) mutant of Bacillus circulans S-11. The structure of S-11-A was elucidated as 1-deamino-1-hydroxyxylostasin, which contains an intermediate of DOS biosynthesis (S-11-P) and has resistance to some aminoglycoside-inactivating enzymes. This is the first finding of antibiotic production by a DOS- mutant without any supplementation of DOS or a DOS analog, and could be described as a novel method of getting a new aminoglycoside antibiotic.
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