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  • Title: Prevention of myocardial Ca overload and necrotization by Mg and K salts or acidosis.
    Author: Janke J, Fleckenstein A, Hein B, Leder O, Sigel H.
    Journal: Recent Adv Stud Cardiac Struct Metab; 1975; 6():33-42. PubMed ID: 743.
    Abstract:
    The crucial point in the pathogenesis of isoproterenol-induced myocardial necrotization is an abundant intracellular Ca accumulation leading to high energy phosphate exhaustion. Accordingly, in the early stage of the isoproterenol-induced necrotization process, the onset of ATP and creatine phosphate breakdown strictly parallels the acute Ca gain. In this type of necrosis, the Mg losses from the myocardium appear as a concomitant phenomenon. The hearts can be protected against the deleterious Ca overload and necrotization by increasing the plasma concentration of Mg, K, or H ions in order to counterbalance Ca according to the ration (see article). On the other hand, if Mg, K, or H ion concentrations are too low, isoproterenol-induced Ca uptake and myocardial lesions are potentiated.
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