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  • Title: Diffuse melanosis in metastatic melanoma. Further evidence for disseminated single cell metastases in the skin.
    Author: Schuler G, Hönigsmann H, Wolff K.
    Journal: J Am Acad Dermatol; 1980 Oct; 3(4):363-9. PubMed ID: 7430457.
    Abstract:
    Electron microscopy (EM) and electron microscopic cytochemistry have shown that diffuse melanosis in advanced metastatic melanoma is the result of an unlimited spread of single melanoma cells throughout the dermis; these cells retain their melanogenic capacity and continue to produce melanized melanosomes which eventually are deposited within dermal macrophages and thus impart to the skin a diffuse slate-blue color. These findings are in accordance with previous observations in a similar patient and thus support the concept that single cell metastasis represents a common pathogenic event in these patients.
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