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  • Title: Morphological study of cleft palate development in 5-fluorouracil-treated hamster fetuses.
    Author: Shah RM, Wong DT.
    Journal: J Embryol Exp Morphol; 1980 Jun; 57():119-28. PubMed ID: 7430925.
    Abstract:
    Morphogenesis of palate was studied in normal and 5-fluorouracil-treated hamster fetuses. The results showed that normal palatal development was completed between days 12 and 13 of gestation. In 5-fluorouracil-assaulted palate the reorientation of shelves from a vertical to horizontal plane was delayed. Crown-rump length, gestational age and fetal weight were reliable predictors of the stages of normal palatal development, whereas the morphological rating system was not. Following 5-fluorouracil treatment, however, crown-rump length, weight and morphological rating were poor indicators of the stage of palatal development.
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