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  • Title: Modal DNA content of human intracranial neoplasms studied by flow cytometry.
    Author: Mørk SJ, Laerum OD.
    Journal: J Neurosurg; 1980 Aug; 53(2):198-204. PubMed ID: 7431058.
    Abstract:
    The relative DNA content in 56 human intracranial tumors was investigated by flow cytometry and correlated to their histological type. Tumors with a modal DNA content within the diploid value (2c) +/- 1/2c were divided from those with heteroploidy. Of the "benign non-neuroepithelial tumors," the meningiomas (five), neurilemomas (two), pituitary adenomas (three), and one hemangioblastoma had a unimodal diploid/near-diploid DNA content. The "malignant non-neuroepithelial tumors" were both heteroploid (two metastatic carcinomas) and diploid/near-diploid (three meningeal fibrosarcomas and one primary malignant lymphoma). Of the neuroepithelial tumors, the highly differentiated gliomas all had a diploid/near-diploid DNA mode except one recurrent oligodendroglioma. The majority of the poorly differentiated gliomas also presented near-diploid DNA modes. Heteroploidy of primary brain tumors was not correlated with a more malignant clinical/biological behavior in the individuals in this study.
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