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  • Title: Early metabolic changes following destruction of the ventromedial hypothalamic nuclei.
    Author: Goldman JK, MacKenzie R, Bernardis LL, Luboshitzky R, Kodis M.
    Journal: Metabolism; 1980 Oct; 29(11):1061-4. PubMed ID: 7432170.
    Abstract:
    Studies were performed to determine whether increased gluconeogenesis precedes or is necessary for increased lipogenesis after ventromedial hypothalamic destruction. Weanling male rats were injected with 14C-bicarbonate or with 3H2O to assess gluconeogenesis or lipogenesis, respectively, at various short time intervals after placement of hypothalamic lesions. Lipogenesis increased within 2 hr of lesion placement whereas gluconeogenesis did not change for at least 4 hr. The results indicate that lipogenesis increases before gluconeogenesis and, therefore, that enhanced glucose production is not necessary for increased lipogenesis to occur in these rats.
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