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  • Title: Highly structured water network in crystals of a deoxydinucleoside---drug complex.
    Author: Neidle S, Berman HM, Shieh HS.
    Journal: Nature; 1980 Nov 13; 288(5787):129-33. PubMed ID: 7432511.
    Abstract:
    X-ray diffraction analysis of crystals of the intercalative complex between the deoxyribonucleoside phosphate d(CpG) and the mutagen proflavine shows a highly structured arrangement of water molecules linked together by newtworks of hydrogen bonds to form four edge-linked pentagons per asymmetric unit. These pentagons have a general role in maximizing hydrogen bonding at 3.4-A intervals. The conformation of the deoxyribose sugar ring at the 3' end of one strand can depend on its local aqueous environment.
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