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  • Title: Safety and toleration of oxymetazoline ophthalmic solution.
    Author: Samson CR, Danzig MR, Sasovetz D, Thompson HS.
    Journal: Pharmatherapeutica; 1980; 2(6):347-52. PubMed ID: 7433475.
    Abstract:
    Two studies were carried out in volunteers without any abnormal ocular conditions to assess the effects and safety of an ophthalmic preparation of oxymetazoline (0.025%). In the first study in which oxymetazoline was compared with placebo and phenylephrine, the results of infra-red electronic pupillography showed that oxymetazoline in therapeutic doses had no effect on pupil size or near point recession. The second study, which was a double-blind forced choice comparison of two different formulations against placebo and 1% naphazoline, showed from assessments of the degree of ocular discomfort and hyperaemia that oxymetazoline was well tolerated and the subjects preferred oxymetazoline in a boric acid rather than in a phosphate solution.
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