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  • Title: [Experimental studies of the treatment of hypotensive blood circulation disorders during sequential ultrafiltration hemodialysis].
    Author: Klinkmann H, Herrera-Valdez R, Holtz M, Schmidt R.
    Journal: Z Gesamte Inn Med; 1980 Jun 01; 35(11):442-6. PubMed ID: 7434835.
    Abstract:
    Particularly in risk patients who in the condition of hyperhydration underwent sequential ultrafiltrations-haemodialysis treatment the decrease of blood pressure which appears in individual cases under the treatment is negatively decisive for the success in therapy. In 33 hyperhydrated patients who underwent dialysis, therefore, with the help of the fourfold concentrated human dry plasma DAB 7 the influence of a combined osmo- and substitution therapy on this circulatory complication was investigated. Under the sequential ultrafiltration by means of application of human dry plasma also at an initial decrease of blood pressure not only a stabilisation, but also an increase of blood pressure is achieved. This favourable circulatory behaviour continues also during the following haemodialysis, Apparently by the application of the human dry plasma physiological compensation mechanisms are evoked by various factors such as pharmacological effects on the excitable structures by sodium, potassium and catecholamines and physical effects on the plasma volume by increase of the osmolality and increase of the oncotic pressure. The use of human dry plasma allows the performance of an ultrafiltration treatment as well as of a haemodialysis in hyperhydrated risk patients who are in a circulatory collapse and thus considerably enlarges the area of indication of the sequential ultrafiltration dialysis treatment.
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